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According to previous studies, certain inflammatory cytokines produced (in vitro) by the NF-B (Nuclear Factor kappa-light-chain-enhancer of activated B cells) signal pathways in response to external stimuli like lipopolysaccharide (LPS), which is enhanced during inflammation, include tumor necrosis factor (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1) [25]